Hiroko NAKATA, Ph.D.

|

Patent Attorney


PROFILE_placeholderDr. Nakata worked as a research associate at the National Defense Medical College. She received a PhD from the University of Tokyo for research on Phosphorylation of muscarinic acetylcholine receptor.

Dr. Nakata then continued her research on signal transduction mechanisms of G-proteins at the Health Sciences Center of Colorado University and the University of Illinois. Upon her return to Japan she worked at the National Center of Neurology and Psychiatry on projects to interpret functional mechanisms of brain-derived neurotrophic factor (BDNF). Dr. Nakata joined the firm in 2013.

Expertise

Biochemistry, Cell Biology, Molecular Biology, Genetic Engineering, Biology, Biotechnology, Medicine, Diagnosis, Pharmacology, Neuroscience

Education

  • PhD, Medical Biochemistry The University of Tokyo
  • MS, Pharmaceutical Physiology Hokkaido University

Publications

  • Nakata H, Nakamura S. “Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling.” FEBS Lett. 2007, 581(10):2047-2054.
  • Nakata H, Kozasa T. “Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1.” Mol Pharmacol. 2005, 67(3):695-702.
  • Hu B, Nakata H, Gu C, De Beer T, Cooper DM. “A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.” J Biol Chem. 2002, 277(36):33139-33147.
  • Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K. “A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.” Blood 2001, 97(10): 3051-60.
  • Rich TC, Fagan KA, Nakata H, Schaack J, Cooper DM, Karpen JW. “Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion.” J Gen Physiol. 2000, 116(2):147-161.
  • Guillou JL, Nakata H, Cooper DM. “Inhibition by calcium of mammalian adenylyl cyclases.” J Biol Chem. 1999, 274(50):35539-35545.
  • Nakata H, Watanabe Y. “Comparative study of p120 GTPase-activating protein and its point mutant in the pleckstrin homology domain.” Cell Signal. 1998, 10(3):211-216.
  • Nakata H, Watanabe Y. “Proliferation and differentiation of PC12 cells were affected by p21ras GTPase activating proteins and its deletion mutant proteins.” Biochem Biophys Res Commun. 1996, 218(2):538-543.
  • Nakata H, Kameyama K, Haga K, Haga T. “Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype).” Eur J Biochem. 1994, 220(1):29-36
  • Haga T, Haga K, Kameyama K, Nakata H. “Phosphorylation of muscarinic receptors: regulation by G proteins.” Life Sci. 1993, 52(5-6):421-428.

Languages

  • Japanese (native)
  • English

Affiliations/Certifications

  • Japan Patent Attorneys Association (JPAA)
  • Pharmacist License

Seminars